ISTO Technologies, Inc. is a clinical stage orthobiologic company located in St. Louis, Missouri. The Company develops highly differentiated products for the sport medicine and spinal markets. ISTO’s product development is focused on cartilage regeneration intended for the repair and renewal of damaged tissues in knee joints and spinal discs. Cartilage regeneration is considered the “holy grail” of the orthopedic industry because renewing cartilage can potentially restore natural function and relieve pain in diseased joints. The Company has a broad range of products in its development pipeline and anticipates having its first commercial product launch in 2007.